• Immuno-suppressive cytokine IL35 

  • Regulation of Treg stability via the Nrp1 pathway

  • Identification of novel Treg molecules and suppressive mechanisms

Selected publications:

 

Collison LW, Workman CJ, Kuo TK, Boyd K, Wang Y, Vignali K, Cross R, Sehy D, Blumberg RS, Vignali DAA (2007). The inhibitory cytokine IL-35 contributes to regulatory T cell function. Nature 450: 566-569 [Pubmed]

Vignali DAA, Collison LW, Workman CJ (2008). How regulatory T cells work. Nature Reviews Immunology 8: 523-532 [Pubmed]

Collison LW, Chaturvedi V, Henderson AL, Giacomin PR, Guy C, Bankoti J, Finkelstein D, Forbes K, Workman CJ, Brown SA, Rehg JE, Jones ML, Ni H-T, Artis D, Turk MJ, Vignali DAA (2010). Interleukin-35-mediated induction of a potent regulatory T cell population. Nature Immunology 11: 1093-1101 [Pubmed]

Vignali DAA, Kurchroo VK (2012). IL-12 Family Cytokines: Immunlogical Playmakers. Nature Immunology 13: 722-728 [Pubmed]

Delgoffe GM*, Woo SR*, Turnis ME, Gravano DM, Guy C, Overacre AE, Bettini ML, Vogel P, Finkelstein D, Bonnevier J, Workman CJ, Vignali DAA (2013). Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis. Nature  501: 252-256 [Pubmed]

Turnis ME*, Sawant DV*, Szymczak-Workman A, Andrews LP, Delgoffe GM, Yano H, Beres AJ, Vogel P, Workman CJ, Vignali DAA (2016). Interleukin-35 limits anti-tumor immunity. Immunity 44: 316-329 [Pubmed]

Overacre-Delgoffe AE, Chikina M, Dadey RE, Yano H, Brunazzi EA, Shayan G, Horne W, Moskovitz JM, Kolls JK, Sander C, Shuai Y, Normolle DP, Kirkwood JM, Ferris RL, Delgoffe GM, Bruno TC, Workman CJ, Vignali DAA (2017). Interferon-gamma drives Treg fragility to promote anti-tumor immunity.  Cell [Pubmed]

Sawant DV*, Yano H*, Chikina M, Zhang Q, Liao M, Liu C, Callahan DJ, Sun Z, Sun T, Tabib T, Pennathur A, Corry DB, Luketich JD, Lafyatis R, Chen W, Poholek AC, Bruno TC, Workman CJ, Vignali DAA (2019). Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion..  Nature Immunology [Pubmed]