​Driving Questions

  • What is the immune landscape in cancer patients?

  • What is the immune landscape in patients prior to developing cancer?

  • What are the unique mechanisms of resistance in patients that do not respond to immunotherapy?

  • How do key immunotherapies alter the baseline immune microenvironment?

Ongoing Projects:

  1. Single cell transcriptional immune landscape of head and neck cancer (HNSCC)

  2. Control of regulatory T cell fragility in the tumor microenvironment

  3. Impact of LAG3 on T cell function in the tumor microenvironment

Selected publications:

 

Cillo AR, Kurten CHL, Tabib T, Qi Z, Onkar S, Wang T, Liu A, Duvvuri U, Kim S, Soose R, Oesterreich S, Chen W, Lafyatis R, Bruno TC, Ferris RL, Vignali DAA (2020). Immune Landscape of Viral- and Carcinogen-Driven Head and Neck Cancer. Immunity 52: 183-199 [Pubmed]