VIGNALI Laboratory

Biochemical analysis of the regulatory T cell protein lymphocyte activation gene-3 (LAG-3; CD223).

Li N, Workman CJ, Martin SM, Vignali DA.

Role of LAG-3 in regulatory T cells.

Huang CT, Workman CJ, Flies D, Pan X, Marson AL, Zhou G, Hipkiss EL, Ravi S, Kowalski J, Levitsky HI, Powell JD, Pardoll DM, Drake CG, Vignali DA.

Diabetes incidence is unaltered in glutamate decarboxylase 65-specific TCR retrogenic nonobese diabetic mice: generation by retroviral-mediated stem cell gene transfer.

Arnold PY, Burton AR, Vignali DA.

Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo.

Workman CJ, Cauley LS, Kim IJ, Blackman MA, Woodland DL, Vignali DA.

Correction of multi-gene deficiency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector.

Szymczak AL, Workman CJ, Wang Y, Vignali KM, Dilioglou S, Vanin EF, Vignali DA.

Architectural changes in the TCR:CD3 complex induced by MHC:peptide ligation.

La Gruta NL, Liu H, Dilioglou S, Rhodes M, Wiest DL, Vignali DA.

CD40-induced aggregation of MHC class II and CD80 on the cell surface leads to an early enhancement in antigen presentation.

Clatza A, Bonifaz LC, Vignali DA, Moreno J.

The CD4-related molecule, LAG-3 (CD223), regulates the expansion of activated T cells.

​Workman CJ, Vignali DA.

Cutting edge: virus-specific CD4+ memory T cells in nonlymphoid tissues express a highly activated phenotype.

Cauley LS, Cookenham T, Miller TB, Adams PS, Vignali KM, Vignali DA, Woodland DL.

Reliable generation and use of MHC class II:gamma2aFc multimers for the identification of antigen-specific CD4(+) T cells.

Arnold PY, Vignali KM, Miller TB, La Gruta NL, Cauley LS, Haynes L, Scott Adams P, Swain SL, Woodland DL, Vignali DA.

Cutting edge: molecular analysis of the negative regulatory function of lymphocyte activation gene-3.

Workman CJ, Dugger KJ, Vignali DA.

Phenotypic analysis of the murine CD4-related glycoprotein, CD223 (LAG-3).

Workman CJ, Rice DS, Dugger KJ, Kurschner C, Vignali DA.

The majority of immunogenic epitopes generate CD4+ T cells that are dependent on MHC class II-bound peptide-flanking residues.

Arnold PY, La Gruta NL, Miller T, Vignali KM, Adams PS, Woodland DL, Vignali DA.

On the dynamics of TCR:CD3 complex cell surface expression and downmodulation.

Liu H, Rhodes M, Wiest DL, Vignali DA.

Multiplexed particle-based flow cytometric assays.

Vignali DA.