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October 18, 2019

J Immunother Cancer

Metastatic breast cancers have reduced immune cell recruitment but harbor increased macrophages relative to their matched primary tumors.

Zhu L, Narloch JL, Onkar S, Joy M, Broadwater G, Luedke C, Hall A, Kim R, Pogue-Geile K, Sammons S, Nayyar N, Chukwueke U, Brastianos PK, Anders CK, Soloff AC, Vignali DAA, Tseng GC, Emens LA, Lucas PC, Blackwell KL, Oesterreich S, Lee AV.

October 14, 2019

Nat Immunol.

nhibitory receptors and ligands beyond PD-1, PD-L1 and CTLA-4: breakthroughs or backups.

Andrews LP, Yano H, Vignali DAA.

September 17, 2019

Semin Immunol.

Lymphocyte-activation gene 3 (LAG3): The next immune checkpoint receptor

Ruffo E, Wu RC, Bruno TC, Workman CJ, Vignali DAA

August 28, 2019


Pancreatic cancer-associated inflammation drives dynamic regulation of p35 and Ebi3.

Michaud D, Mirlekar B, Bischoff S, Cowley DO, Vignali DAA, Pylayeva-Gupta Y.

August 20, 2019


Treg Cells Promote the SREBP1-Dependent Metabolic Fitness of Tumor-Promoting Macrophages via Repression of CD8+ T Cell-Derived Interferon-γ.

July 01, 2019


Intratumoral regulatory T cells: markers, subsets and their impact on anti-tumor immunity.

Yano H, Andrews LP, Workman CJ, Vignali DAA.

June 01, 2019

Nature Immunology

Adaptive plasticity of IL-10+ and IL-35+ Treg cells cooperatively promotes tumor T cell exhaustion.

Sawant DV, Yano H, Chikina M, Zhang Q, Liao M, Liu C, Callahan DJ, Sun Z, Sun T, Tabib T, Pennathur A, Corry DB, Luketich JD, Lafyatis R, Chen W, Poholek AC, Bruno TC, Workman CJ, Vignali DAA.

April 09, 2019

Nature Communications

A Bayesian mixture model for clustering droplet-based single-cell transcriptomic data from population studies.

Sun Z, Chen L, Xin H, Jiang Y, Huang Q, Cillo AR, Tabib T, Kolls JK, Bruno TC, Lafyatis R, Vignali DAA, Chen K, Ding Y, Hu M, Chen W.

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