Biology of LAG3/PD1, IL-35 and Nrp1 in mouse models of cancer.
Impact and function of Tregs and inhibitory receptors in the several autoimmune and inflammatory disease with emphasis on models of autoimmune diabetes (NOD mouse model), EAE and asthma; development of approaches to enhance Treg stability and function; therapeutic delivery approaches to promote IL-35, Nrp1 and LAG3 function.
Bettini M, Vignali DAA (2011). T cell-driven initiation and propagation of autoimmune diabetes. Current Opinion in Immunology 23: 754-760 [Pubmed]
Herold KC, Vignali DAA, Cooke A, Bluestone JA (2012). Type I diabetes: translating mechanistic observations into effective clinical outcomes. Nature Review Immunology 13: 243-256 [Pubmed]
Vignali DAA (2013). Interview: Immunotherapeutic manipulation of the tumor microenvironment. Immunotherapy 5: 1279-1281 [Pubmed]
Andrews LP, Marciscano AE, Drake CG, Vignali DAA (2017). LAG3 (CD223) as a cancer immunotherapy target. Immunological Reviews 276: 80-96 [Pubmed]