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July 17, 2020

It has been a busy time for the Vignali Lab.  Over the past week 3 manuscripts from the lab were published in Nature Immunology, Science Immunology, and the Journal for the ImmunoTherapy of Cancer.  Eager for more that are in the pipeline!  Major congratulations to the first authors including Chang (Gracie) Liu PhD (NI and JITC), Lawrence Andrews PhD (SI), and Chris Chuckran (JITC).

Liu C, et al. Neuropilin-1 is a T cell memory checkpoint limiting long-term antitumor immunity. Nature Immunology. 12 July 2020; DOI: 10.1038/s41590-020-0733-2

Chuckran CA, Liu C, et al. Neuropilin-1: a checkpoint target with unique implications for cancer immunology and immunotherapy. Journal for ImmunoTherapy of Cancer 2020;8:e000967. doi:10.1136/ jitc-2020-000967

Andrews LP, et al. Resistance to PD1 blockade in the absence of metalloprotease-mediated LAG3 shedding. Science Immunology. 17 July 2020; DOI: 10.1126/sciimmunol.abc2728.

November 26, 2019

Post-doctoral researcher, Angela Gocher, received funding for her F32 grant submission (F32CA247004) entitled "Production of Interferon Gamma by Regulatory T Cells Mediates Response to Immunotherapy".  Congratulations on this achievement!

October 02, 2019

4th year graduate student Christopher Chuckran won a poster award at the 2019 BGSA Symposium in addition to receiving his "Most Well-Rounded Student" award!

October 02, 2019

Christopher Chuckran was named the University of Pittsburgh Biomedical Graduate Student Association's "Most Well-Rounded Student" for 2019 based on his academic achievements, leadership as CEO of Fourth River Solutions, and investment in the Pitt graduate training environment.  Chris was selected from all non-MD graduate student nominations within the School of Medicine for this award. Congratulations on this distinct honor!

August 16, 2019

In addition to Rebekah Dadey, graduate students Christopher Chuckran (rising 4th year) and Stephanie Grebinoski (rising 3rd year) received notices of award for their respective F31 submissions.  The Vignali Lab is extraordinarily proud of the accomplishments of these graduate students and the high level of achievement maintained in the lab!  Congratulations Becky, Chris, and Steph!

July 11, 2019

Second year graduate student Stephanie Grebinoski was invited to present her work at the Autoimmunity FASEB Science Research Conference (SRC).  Her talk, entitled "LAG3 limits diabetogenicity of intra-islet CD8 T cells" demonstrated that CD8-restricted LAG3 deletion nearly phenocopies LAG3 global knockout in NOD mice, indicating that the main role for LAG3 in this model is to restrict CD8 T reaction to islet autoantigens.

June 18, 2019

Graduate student Becky Dadey was awarded an F31 grant for her project entitled "IFN-y drives Treg fragility through DNA methylation of the Treg-specific de-methylated regions".  Join us in congratulating Becky on this impressive accomplishment and the fulfillment of much time and hard work!

April 27, 2019

At the IMMUNO-ONCOLOGY Young Investigator Forum in Houston, TX, both Ashwin Somasundaram M.D. and Anthony Cillo PhD won 1st place prizes in their respective Clinical Fellow and Research Fellow sections.  The whole lab is extremely proud of this impressive showing!

March 05, 2019

Following his talk at the 2019 IASLC Targeted Therapies meeting, Ashwin Somasundaram MD received the IASLC Foundation Young Investigator Award.  The award provides substantial funding for one year of Ashwin's continuing research.

January 24, 2019

Clinical fellow Ashwin Somasundaram MD was asked to present an abstract of his work at the International Association for the Study of Lung Cancer (IASLC) 2019 Targeted Therapies Meeting in February.  Ashwin's was one of just 3 abstracts selected for an oral presentation.  Congratulations Ashwin on this prestigious honor!

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